Inhibitory role of gamma-amino-butyric acid in the rabbit urinary bladder.

@article{Chen1992InhibitoryRO,
  title={Inhibitory role of gamma-amino-butyric acid in the rabbit urinary bladder.},
  author={Terng F Chen and Peter T Doyle and Douglas R Ferguson},
  journal={British journal of urology},
  year={1992},
  volume={69 1},
  pages={
          12-6
        }
}
Gamma-amino-butyric acid (GABA) is an established inhibitory neurotransmitter in the central nervous system (CNS) and it has also been identified in the bladder. We have investigated in the rabbit the effect of GABA on detrusor activity. Rabbit detrusor muscle strips were made to contract by electrical stimulation of their autonomic nerves or by the addition of carbachol. The addition of GABA caused substantial inhibition of muscle contraction. GABA acts on 2 classes of receptors-GABAA and… CONTINUE READING