Inhibitory regulation of acid-sensing ion channel 3 by zinc.

  title={Inhibitory regulation of acid-sensing ion channel 3 by zinc.},
  author={Qian Jiang and Christopher J. Papasian and John Q Wang and Z. G. Xiong and X P Chu},
  volume={169 2},
Acid-sensing ion channel 3 (ASIC3) is a proton-gated, voltage-insensitive Na(+) channel that is expressed primarily in peripheral sensory neurons and plays an important role in pain perception, particularly as a pH sensor following cardiac ischemia. We previously reported that ASIC3 currents are not affected by zinc at nanomolar concentrations. In this study, we examined the potential role of micromolar zinc in the regulation of ASIC3. In CHO cells expressing ASIC3, we found that ASIC3 currents… CONTINUE READING

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