Inhibitory receptors, ITIM sequences and phosphatases.

  title={Inhibitory receptors, ITIM sequences and phosphatases.},
  author={Jay C. Unkeless and Jing Jin},
  journal={Current opinion in immunology},
  volume={9 3},
A diverse group of inhibitory receptors, including FcgammaRII, killer cell inhibitory receptors, and B22, shares an immunoreceptor tyrosine-based inhibition motif (ITIM). Recent studies have shown that this motif, when phosphorylated on tyrosine, forms a docking site for the Src homology 2 recognition domains of the protein tyrosine phosphatase SHP-1 and the inositol 5-phosphatase SHIP. A similar motif in cytotoxic T-lymphocyte antigen-4 recruits the related tyrosine phosphatase SHP-2. These… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 50 extracted citations

Similar Papers

Loading similar papers…