Inhibitory receptors, ITIM sequences and phosphatases.

@article{Unkeless1997InhibitoryRI,
  title={Inhibitory receptors, ITIM sequences and phosphatases.},
  author={Jay C. Unkeless and Jing Jin},
  journal={Current opinion in immunology},
  year={1997},
  volume={9 3},
  pages={338-43}
}
A diverse group of inhibitory receptors, including FcgammaRII, killer cell inhibitory receptors, and B22, shares an immunoreceptor tyrosine-based inhibition motif (ITIM). Recent studies have shown that this motif, when phosphorylated on tyrosine, forms a docking site for the Src homology 2 recognition domains of the protein tyrosine phosphatase SHP-1 and the inositol 5-phosphatase SHIP. A similar motif in cytotoxic T-lymphocyte antigen-4 recruits the related tyrosine phosphatase SHP-2. These… CONTINUE READING

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