Inhibitory receptor-mediated regulation of natural killer cells.

  title={Inhibitory receptor-mediated regulation of natural killer cells.},
  author={Elisenda Alari-Pahissa and Camille Grandcl{\'e}ment and Beena Patricia Jeevan-Raj and Werner Held},
  journal={Critical reviews in immunology},
  volume={34 6},
Natural killer (NK) cells are capable of directly recognizing pathogens, pathogen-infected cells, and transformed cells. NK cells recognize target cells using approximately 100 germ-line encoded receptors, which display activating or inhibitory function. NK cell activation usually requires the engagement of more than one receptor, and these may contribute distinct signaling inputs that are required for the firm adhesion of NK cells to target cells, polarization, and the release of cytotoxic… CONTINUE READING