Inhibitory receptor FcγRIIb mediates the effects of IgG on a phagosome acidification and a sequential dephosphorylation system comprising SHIPs and Inpp4a.

Abstract

The relative abundance of phosphoinositide (PI) species on the phagosome membrane fluctuates over the course of phagocytosis. PtdIns(3,4,5)P3 and PtdIns(3,4)P2 rapidly increase in the forming of the phagocytic cup, following which they disappear after sealing of the cup. In the present study, we monitored the clearance of these PI species using the enhanced… (More)
DOI: 10.1177/1753425917701553

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@article{Segawa2017InhibitoryRF, title={Inhibitory receptor FcγRIIb mediates the effects of IgG on a phagosome acidification and a sequential dephosphorylation system comprising SHIPs and Inpp4a.}, author={Tomohiro Segawa and Kaoru Hazeki and Kiyomi Nigorikawa and Atsuko Nukuda and Tomoki Tanizawa and Kenshiro Miyamoto and Shin Morioka and Osamu Hazeki}, journal={Innate immunity}, year={2017}, volume={23 4}, pages={401-409} }