Inhibitory properties of a bovine pineal tripeptide, threonylseryllysine, on serum follicle-stimulating hormone.

@article{Orts1980InhibitoryPO,
  title={Inhibitory properties of a bovine pineal tripeptide, threonylseryllysine, on serum follicle-stimulating hormone.},
  author={R J Orts and Brent C. Bruot and James L. Sartin},
  journal={Neuroendocrinology},
  year={1980},
  volume={31 2},
  pages={
          92-5
        }
}
Administration of the bovine pineal peptide threonylseryllysine (TSL) to unilaterally ovariectomized (UO) mice as a single intraperitoneal injection on the day of UO reduced the 5-day compensatory ovarian hypertrophy. The same dose of TSL (175 ng/animal) significantly (p less than 0.01) reduced serum follicle stimulating hormone (FSH) in UO mice 24 h after surgery and administration of the peptide. In other experiments, adult male rats were anesthetized with urethane and given an intravenous… Expand
Bovine Pineal Tripeptide Threonylseryllysine Retards Puberty in Female Rats
  • B. Benson
  • Biology, Medicine
  • Journal of pineal research
  • 1989
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The present results strongly support the view that inhibin‐like activity may be the major player in what has so far been referred to as antigonadotropic activity. Expand
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The data indicating a central nervous point of attack of pineal indoles that influence the secretion of the hypothalamic releasing hormones is summarized. Expand
Mode of action of inhibin‐like pineal antigonadotropin is different from melatonin during compensatory ovarian hypertrophy
Bhagat L, Duraiswami S, Muralidhar K. Mode of action of inhibin‐like pineal antigonadotropin is different from melatonin during compensatory ovarian hypertrophy. J. Pineal Res. 1994:16:193–197.
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The data suggest that structure and function are integrally related from the earliest steps of receptor–ligand evolution so that peptide functionality is non‐random and highly conserved in its origin. Expand
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It is argued that screening for molecular complementarity of small molecules turns ligands such as neurotransmitters and their metabolites, hormones, and drugs themselves, into direct targets of drug development that can augment screening new compounds for activity against receptors and second messenger systems. Expand