Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro.

@article{Fuhr1992InhibitoryPO,
  title={Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro.},
  author={Uwe Fuhr and E. Margot Anders and Gerhard Mahr and Fritz Soergel and Alfred H. Staib},
  journal={Antimicrobial agents and chemotherapy},
  year={1992},
  volume={36 5},
  pages={
          942-8
        }
}
Inhibition of cytochrome P450IA2 activity is an important adverse effect of quinolone antibacterial agents. It results in a prolonged half-life for some drugs that are coadministered with quinolones, such as theophylline. The objective of the study described here was to define the parameters for quantifying the inhibitory potencies of quinolones against cytochrome P450IA2 in vivo and in vitro and to investigate the relationship between the results of both approaches. Cytochrome P450IA2 activity… CONTINUE READING
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