Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase.

@article{Feng1999InhibitoryPS,
  title={Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase.},
  author={Jian Xun Feng and Masaaki Ito and Kenji Ichikawa and Naoki Isaka and Masakatsu Nishikawa and David J. Hartshorne and Tetsuo Nakano},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 52},
  pages={37385-90}
}
It is clear from several studies that myosin phosphatase (MP) can be inhibited via a pathway that involves RhoA. However, the mechanism of inhibition is not established. These studies were carried out to test the hypothesis that Rho-kinase (Rho-associated kinase) via phosphorylation of the myosin phosphatase target subunit 1 (MYPT1) inhibited MP activity and to identify relevant sites of phosphorylation. Phosphorylation by Rho-kinase inhibited MP activity and this reflected a decrease in V(max… CONTINUE READING
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