Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.

  title={Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.},
  author={Tarsis Ferreira Gesteira and Vivien J Coulson-Thomas and Alessandro Taunay-Rodrigues and Vitor Oliveira and Bryan Edward Thacker and Maria Aparecida Juliano and Renata Pasqualini and Wadih Arap and Ivarne L. S. Tersariol and Helena B. Nader and Jeffrey D Esko and Maria A S Pinhal},
  journal={The Journal of biological chemistry},
  volume={286 7},
N-Deacetylase-N-sulfotransferase 1 (Ndst1) catalyzes the initial modification of heparan sulfate and heparin during their biosynthesis by removal of acetyl groups from subsets of N-acetylglucosamine units and subsequent sulfation of the resulting free amino groups. In this study, we used a phage display library to select peptides that interact with Ndst1, with the aim of finding inhibitors of the enzyme. The phage library consisted of cyclic random 10-mer peptides expressed in the phage capsid… CONTINUE READING

From This Paper

Figures and tables from this paper.


Publications citing this paper.
Showing 1-10 of 10 extracted citations


Publications referenced by this paper.
Showing 1-5 of 5 references

Insights into Carbohydrate Structure and Biological Function

L. O. Sampaio, I.L.S. Tersariol, +4 authors H. B. Nader
View 1 Excerpt

Department of Biochemistry and Molecular by gest on O cber 5, 2017 hp://w w w D ow nladed from 12 Biology, University College London

S.J.T. Hubbard, M J.
View 1 Excerpt

hp://w w w D

S. E. Cwirla, E. A. Peters, R. W. Barrett, W. J. Dower
Proc Natl Acad Sci U S A87, • 1990
View 1 Excerpt

Similar Papers

Loading similar papers…