Inhibitory peptides in hematopoiesis.

  title={Inhibitory peptides in hematopoiesis.},
  author={Martine Guigon and Dominique Bonnet},
  journal={Experimental hematology},
  volume={23 6},
This paper will review the present knowledge on two small chemically unrelated peptides, the pentapeptide pGlu-Glu-Asp-Cys-Lys (pEEDCK) and the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (AcSDKP, Seraspenide) focusing on 1) their inhibitory effects on normal hematopoiesis, 2) their effect on malignant cells, especially leukemic cells, and 3) their potential clinical use as marrow protectors during cancer therapy.