Inhibitory molecules that regulate expansion and restoration of HCV-specific CD4+ T cells in patients with chronic infection.

@article{Raziorrouh2011InhibitoryMT,
  title={Inhibitory molecules that regulate expansion and restoration of HCV-specific CD4+ T cells in patients with chronic infection.},
  author={Bijan Raziorrouh and Axel Ulsenheimer and Winfried W Schraut and Malte H.J. Heeg and Peter D. Kurktschiev and Reinhart Zachoval and M. C. Jung and Robert Thimme and Christoph Neumann-Haefelin and Sophia Horster and Martin W{\"a}chtler and Michael Spannagl and Juergen Dipl Ing Haas and Helmut Michael Diepolder and Norbert Hubert Gruener},
  journal={Gastroenterology},
  year={2011},
  volume={141 4},
  pages={
          1422-31, 1431.e1-6
        }
}
BACKGROUND & AIMS Inhibitory receptors such as programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen (CTLA)-4 mediate CD8+ T-cell exhaustion during chronic viral infection, but little is known about roles in dysfunction of CD4+ T cells. METHODS We investigated the functions of inhibitory molecules on hepatitis C virus (HCV)-, influenza-, and Epstein-Barr virus (EBV)-specific CD4+ T cells in patients with chronic infections compared with patients with resolved HCV infection… CONTINUE READING
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