Inhibitory modulation of distal C-terminal on protein kinase C-dependent phospho-regulation of rat TRPV1 receptors.

@article{Liu2004InhibitoryMO,
  title={Inhibitory modulation of distal C-terminal on protein kinase C-dependent phospho-regulation of rat TRPV1 receptors.},
  author={Beiying Liu and Weijun Ma and Sujung Ryu and Feng Qin},
  journal={The Journal of physiology},
  year={2004},
  volume={560 Pt 3},
  pages={627-38}
}
The vanilloid receptor TRPV1, previously known as VR1, has been implicated in pain sensation under both physiological and pathological conditions. The channel is highly expressed in sensory ganglion neurones and is activated by a range of noxious stimuli including irritant chemicals, acids and heat. In order to understand the structural basis underlying this polymodal activation and the regulation by intracellular signalling pathways, we have investigated the functional roles of the cytoplasmic… CONTINUE READING