Inhibitory mechanisms of antibiotics targeting elongation factor Tu.

  title={Inhibitory mechanisms of antibiotics targeting elongation factor Tu.},
  author={Tanis Hogg and Jeroen R. Mesters and Rolf Hilgenfeld},
  journal={Current protein & peptide science},
  volume={3 1},
Since the pioneering discovery of the inhibitory effects of kirromycin on bacterial elongation factor Tu (EF-Tu) more than 25 years ago [1], a great wealth of biological data has accumulated concerning protein biosynthesis inhibitors specific for EF-Tu. With the subsequent discovery of over two dozen naturally occurring EF-Tu inhibitors belonging to four different subclasses, EF-Tu has blossomed into an appealing antimicrobial target for rational drug discovery efforts. Very recently… CONTINUE READING

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