Inhibitory mechanism of Ca2+ on the hemolysis caused by Vibrio vulnificus cytolysin.

@article{Park1994InhibitoryMO,
  title={Inhibitory mechanism of Ca2+ on the hemolysis caused by Vibrio vulnificus cytolysin.},
  author={J. Park and T. Jahng and H. Rho and B. H. Park and N. H. Kim and H. Kim},
  journal={Biochimica et biophysica acta},
  year={1994},
  volume={1194 1},
  pages={
          166-70
        }
}
Calcium in millimolar concentrations protected mouse erythrocytes from hemolysis caused by Vibrio vulnificus cytolysin without affecting the release of intracellular K+ from the cells. This effect was maximal at 25 mM CaCl2. The protection was not absolute and could be partially overcome by increased concentrations of cytolysin. Calcium failed to block both the binding and oligomer formation of cytolysins on the erythrocyte membrane. After pore formation, the continued presence of calcium is… Expand
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