Inhibitory masking controls the threshold sensitivity of retinal ganglion cells.

  title={Inhibitory masking controls the threshold sensitivity of retinal ganglion cells.},
  author={Feng Pan and Abduqodir H. Toychiev and Yi Zhang and Tam{\'a}s Atlasz and Hariharasubramanian Ramakrishnan and Kaushambi Roy and B{\'e}la V{\"o}lgyi and Abram Akopian and Stewart A. Bloomfield},
  journal={The Journal of physiology},
  volume={594 22},
KEY POINTS Retinal ganglion cells (RGCs) in dark-adapted retinas show a range of threshold sensitivities spanning ∼3 log units of illuminance. Here, we show that the different threshold sensitivities of RGCs reflect an inhibitory mechanism that masks inputs from certain rod pathways. The masking inhibition is subserved by GABAC receptors, probably on bipolar cell axon terminals. The GABAergic masking inhibition appears independent of dopaminergic circuitry that has been shown also to affect RGC… CONTINUE READING
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