Inhibitory machinery for the TGF-β family signaling pathway.

  title={Inhibitory machinery for the TGF-β family signaling pathway.},
  author={Susumu Itoh and F. Itoh},
  journal={Growth factors},
  volume={29 5},
Transforming growth factor-β (TGF-β) family signaling regulates cell growth and differentiation of many different cell types and is widely involved in the regulation of homeostasis during both embryogenesis and adult life. Therefore, aberrant TGF-β family signal transduction is linked to congenital disorders, tumorigenicity, and fibrosis, which can be life-threatening. A specific receptor-ligand complex initiates transduction of TGF-β family signaling to the nucleus via intracellular signal… CONTINUE READING


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