Inhibitory ligand-gated ion channels as substrates for general anesthetic actions.

@article{Zeller2008InhibitoryLI,
  title={Inhibitory ligand-gated ion channels as substrates for general anesthetic actions.},
  author={Anja Zeller and Rachel Jurd and Sebastian Lambert and Michael Arras and Berthold Drexler and Carsten Grashoff and Bernd Antkowiak and Uwe Rudolph},
  journal={Handbook of experimental pharmacology},
  year={2008},
  volume={182},
  pages={31-51}
}
General anesthetics have been in clinical use for more than 160 years. Nevertheless, their mechanism of action is still only poorly understood. In this review, we describe studies suggesting that inhibitory ligand-gated ion channels are potential targets for general anesthetics in vitro and describe how the involvement of y-aminobutyric acid (GABA)(A) receptor subtypes in anesthetic actions could be demonstrated by genetic studies in vivo.