Inhibitory interactions of the bradykinin B2 receptor with endothelial nitric-oxide synthase.

@article{Ju1998InhibitoryIO,
  title={Inhibitory interactions of the bradykinin B2 receptor with endothelial nitric-oxide synthase.},
  author={Hong Ju and Virginia J. Venema and Mario B. Marrero and R. Venema},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 37},
  pages={24025-9}
}
It has been shown previously that the endothelial nitric-oxide synthase (eNOS) interacts reversibly with the plasmalemmal caveolae structural protein, caveolin-1. The eNOS-caveolin-1 interaction inhibits eNOS catalytic activity. In the present study, we show that eNOS also participates in reversible inhibitory interactions with the G protein-coupled bradykinin B2 receptor. eNOS and the B2 receptor are coimmunoprecipitated from endothelial cell lysates by antibodies directed against either of… CONTINUE READING