Inhibitory effects of vincristine, ifosfamide and peplomycin on hormone-independent human prostatic carcinoma cell line.

Abstract

The sensitivity of a hormone-independent human prostatic carcinoma cell line (PC-3) to anticancer drugs was evaluated in vitro. The anticancer drugs used were vincristine sulfate (VCR), peplomycin sulfate (PLM) and 4-hydroperoxyisophosphamide (4-HIF), i.e., an form of ifosfamide (IFOS) in vivo. The inhibitory effect of 4-HIF alone and of the combination of VCR, 4-HIF and PLM (VIP) on the cell proliferation was almost the same. Furthermore, among the 6 groups treated with 2 of the 3 drugs mentioned above the most potent inhibitory effect was obtained in the group with combined treatment of 4-HIF plus PLM.

Cite this paper

@article{MoriyamaGonda1988InhibitoryEO, title={Inhibitory effects of vincristine, ifosfamide and peplomycin on hormone-independent human prostatic carcinoma cell line.}, author={Nobuko Moriyama-Gonda and Motonori Mizutani and Shigeru Ehara and Tomoaki Usui and Tomoyuki Ishibe}, journal={Experimental pathology}, year={1988}, volume={35 3}, pages={141-8} }