Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes.

@article{Yeo2001InhibitoryEO,
  title={Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes.},
  author={Karen Rowland Yeo and Wilfred W Yeo},
  journal={British journal of clinical pharmacology},
  year={2001},
  volume={51 5},
  pages={461-70}
}
AIMS To determine the effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes and to compare their inhibitory potencies and CYP3A4 inactivation parameters with those reported previously for mibefradil. METHODS Simvastatin metabolism was investigated in human liver microsomes in the presence and absence of verapamil or diltiazem (0.1-250 microM). Kinetics of CYP3A4 inactivation by verapamil and diltiazem were determined using testosterone as the substrate… CONTINUE READING

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