Inhibitory effects of tetrandrine and related synthetic compounds on angiogenesis in streptozotocin-diabetic rodents.

@article{Kobayashi1999InhibitoryEO,
  title={Inhibitory effects of tetrandrine and related synthetic compounds on angiogenesis in streptozotocin-diabetic rodents.},
  author={Shinjiro Kobayashi and Ikuko Kimura and Mizuki Fukuta and Hitoshi Kontani and Kazunori Inaba and Masatake Niwa and Shiro Mita and Midori Kimura},
  journal={Biological & pharmaceutical bulletin},
  year={1999},
  volume={22 4},
  pages={360-5}
}
Structure-activity relationships of tetrandrine, isolated from a Kampo medicine, Stephania tetrandrae S. MOORE (root), and related synthetic compounds, were investigated in in vitro fetal bovine serum (FBS)-stimulated angiogenesis of cultured choroids in streptozotocin-diabetic Wistar rats, and air-pouch granuloma angiogenesis in vivo in diabetic mice. Tetrandrine, KS-1-1 (6,7-dimethoxy-1-[[4-[5-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroiso quinolinyl)methyl-2-methoxy]phenoxy]benzyl]-2-methyl-1… CONTINUE READING

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