Inhibitory effects of tea catechins and O-methylated derivatives of (-)-epigallocatechin-3-O-gallate on mouse type IV allergy.

  title={Inhibitory effects of tea catechins and O-methylated derivatives of (-)-epigallocatechin-3-O-gallate on mouse type IV allergy.},
  author={M. Suzuki and K. Yoshino and M. Maeda-Yamamoto and T. Miyase and M. Sano},
  journal={Journal of agricultural and food chemistry},
  volume={48 11},
The inhibitory effects of tea catechins, the O-methylated derivatives of (-)-epigallocatechin-3-O-gallate (EGCG), and the polyphenol extracts from tea leaves (Camellia sinensis L.) on oxazolone-induced type IV allergy in male ICR mice were investigated. Four major tea catechins and two O-methylated derivatives, (-)-epigallocatechin-3-O-(3-O-methyl)gallate (EGCG3' 'Me) and (-)-epigallocatechin-3-O-(4-O-methyl)gallate (EGCG4' 'Me), showed significant inhibitory effects on mouse type IV allergy… Expand
Epicatechin-3-O-(3″-O-methyl)-gallate content in various tea cultivars (Camellia sinensis L.) and its in vitro inhibitory effect on histamine release.
Investigation of the effect of various tea leaf catechins on histamine release from murine bone marrow mast cells suggests that ECG3″Me might link to the antiallergic effect of 'Benifuuki' tea, as has been reported for EGCG3′Me. Expand
Comparison of (-)-epigallocatechin-3-O-gallate (EGCG) and O-methyl EGCG bioavailability in rats.
The results suggested that the higher AUC of EGCG3″Me after oral administration was related to its high bioavailability and low distribution volume, and supported the stronger bioactivity of E GCG 3″Me in vivo. Expand
Investigation of epigallocatechin-3-O-caffeoate and epigallocatechin-3-O-p-coumaroate in tea leaves by LC/MS-MS analysis.
The potent antioxidant EGCCA is found using LC-MS/MS and revealed its wide existence in various tea leaves. Expand
Cloning of a novel O-methyltransferase from Camellia sinensis and synthesis of o-methylated EGCG and evaluation of their bioactivity.
Results indicated that reducing the number of hydroxyl groups decreases the effectiveness of DPPH radical scavenging and antibacterial activity, and EGCG was the most effective of the O-methylated EGCGs. Expand
Changes in Epigallocatechin-3-O-(3-O-methyl) Gallate and Strictinin Contents of Tea (Camellia sinensis L.) Cultivar ‘Benifuki’ in Various Degrees of Maturity and Leaf Order
To obtain the anti-allergic benefits of EGCG3″Me, green tea should be made from fully-matured ‘Benifuki’ leaves under the fourth shoot late in the first crop or under the third shoot in the second crop, refined by removing stems. Expand
Separation of catechins and O-methylated (-)-epigallocatechin gallate using polyamide thin-layer chromatography.
Thin-layer chromatography (TLC) method for the separation and quantitative determination of seven related compounds has been developed and the applicability of the method was checked by screening of extracts of green, black, oolong, white tea and tea cultivars leaves. Expand
Effect of green tea powder (Camellia sinensis L. cv. Benifuuki) particle size on O-methylated EGCG absorption in rats; The Kakegawa Study
Tea polyphenols, e.g., (-)-epigallocatechin-3-O-(3-O-methyl gallate (EGCG3”Me), (-)-epigallocatechin-3-O-gallate (EGCG), (-)-epigallocatechin (EGC), (-)-epicatechin-3-O-gallate (ECG), andExpand
Effects of Oolong tea polyphenols, EGCG, and EGCG3″Me on pancreatic α-amylase activity in vitro.
The results showed that Oolong tea polyphenols, E GCG, and EGCG3″Me all exhibited inhibitory effects against α-amylase, and their half inhibitory concentration values were 0.375, 0.350, and 0.572 mg/mL. Expand
O-Methylated Catechins from Tea Leaves Inhibit Multiple Protein Kinases in Mast Cells1
These catechins inhibit IgE/Ag-induced calcium response as well as the activation of downstream serine/threonine kinases such as Akt and c-Jun N-terminal kinase, and for the first time have revealed the molecular mechanisms of antiallergic effects of tea-derived catechINS. Expand
Changes in O-methylated Catechin and Chemical Component Contents of 'Benifuuki' Green Tea (Camellia sinensis L.) Beverage under Various Extraction Conditions
We examined the effects of extraction conditions on the anti-allergic components, epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3″Me) and strictinin during the manufacture of anti-allergicExpand