Inhibitory effects of streptozotocin, tumor necrosis factor-alpha, and interleukin-1beta on glucokinase activity in pancreatic islets and gene expression of GLUT2 and glucokinase.

@article{Park1999InhibitoryEO,
  title={Inhibitory effects of streptozotocin, tumor necrosis factor-alpha, and interleukin-1beta on glucokinase activity in pancreatic islets and gene expression of GLUT2 and glucokinase.},
  author={Chang Hee Park and Jae Ryong Kim and Jae Kwang Shim and Bong Seok Kang and Yun Gyu Park and Kyung Soo Nam and Young Chul Lee and Choong Hoe Kim},
  journal={Archives of biochemistry and biophysics},
  year={1999},
  volume={362 2},
  pages={217-24}
}
Treatment of streptozotocin (ST), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) resulted in destroying insulin-secreting beta-cells of pancreatic islets and impairment of islet glucose oxidation and glucose-induced insulin secretion. IL-1beta and TNF-alpha inhibited insulin release and glucose utilization and oxidation. It was shown that the inhibitory effects of ST, IL-1beta, and TNF-alpha were due to impaired glucokinase activity. Glucokinase activity was severely… CONTINUE READING

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