Inhibitory effects of selenium on the growth of L1210 leukemic cells.

  title={Inhibitory effects of selenium on the growth of L1210 leukemic cells.},
  author={John A. Milner and Chung Yao Hsu},
  journal={Cancer research},
  volume={41 5},
Selenium has been shown to inhibit L1210 cells both in vitro and in vivo. The death of L1210 cells in vitro as indicated by trypan blue exclusion was dependent upon the form and concentration of selenium tested. Incubation of L1210 cells in buffer containing selenium at 1 microgram/ml for 1 hr prior to inoculation into mice significantly retarded the ability of the cells to propagate in vivo. Sodium selenite injected i.p. increased the longevity of mice inoculated with L1210 cells… CONTINUE READING


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