Inhibitory effects of procaine on the contractile responses of the guinea-pig Taenia caecum to acetylcholine, substance P and potassium chloride

@article{Ishii2004InhibitoryEO,
  title={Inhibitory effects of procaine on the contractile responses of the guinea-pig Taenia caecum to acetylcholine, substance P and potassium chloride},
  author={T Ishii and Yasuo Shimo},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={326},
  pages={175-180}
}
  • T. Ishii, Y. Shimo
  • Published 1 June 1984
  • Biology, Medicine, Chemistry
  • Naunyn-Schmiedeberg's Archives of Pharmacology
SummaryThe effect of procaine on the contractile responses to acetylcholine, substance P and KCl was investigated using the isolated guinea-pig taenia caecum. In normal Tyrode solution (37°C), procaine (10–100 μmol/l) caused a parallel shift to the right of only the dose-response curve of acetylcholine (pA2 value, 5.11). The pA2 value of procaine against acetylcholine was not significantly affected by increasing the Ca concentration in the bathing solution from 0.9 to 7.2 mmol/l. On the other… 
Cooling-induced supersensitivity to acetylcholine in the isolated airway smooth muscle of the rat
  • T. IshiiY. Shimo
  • Biology, Medicine
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
TLDR
It is concluded that increased responsiveness of the rat airway smooth muscle to acetylcholine with lowered temperature may involve the acceleration of Ca release from intracellular storage sites, inhibition of Ca extrusion from the cell and or the inhibition ofCa reuptake by intrace cellular storage sites.
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It is concluded that increased responsiveness of the rat anococcygeus muscle to noradrenaline with lowered temperature may involve the inhibition of neuronal uptake mechanism of the catecholamine andThe inhibition of removal mechanism of Ca2+ which is released from intracellular stores associated with the postsynaptic α1-adrenoceptors.
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