Inhibitory effects of omega-3 polyunsaturated fatty acids on receptor-mediated non-selective cation currents in rat A7r5 vascular smooth muscle cells.

@article{Asano1997InhibitoryEO,
  title={Inhibitory effects of omega-3 polyunsaturated fatty acids on receptor-mediated non-selective cation currents in rat A7r5 vascular smooth muscle cells.},
  author={Masahide Asano and Toshiaki Nakajima and Kuniaki Iwasawa and Hiroaki Hazama and Masao Omata and Masaaki Soma and Kamejiro Yamashita and Yukichi Okuda},
  journal={British journal of pharmacology},
  year={1997},
  volume={120 7},
  pages={1367-75}
}
1. The effects of omega-3 polyunsaturated fatty acids on receptor-mediated non-selective cation current (Icat) and K+ current were investigated in aortic smooth muscle cells from foetal rat aorta (A7r5 cells). The whole-cell voltage clamp technique was employed. 2. With a K(+)-containing solution, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA, 30 microM) produced an outward current at a holding potential of -40 mV. This response was inhibited by tetraethylammonium (20 mM) or Cs+ in… CONTINUE READING