Inhibitory effects of novel integrin-targeting peptides on angiogenesis activity in HUVEC cells in vitro.

@article{Liu2011InhibitoryEO,
  title={Inhibitory effects of novel integrin-targeting peptides on angiogenesis activity in HUVEC cells in vitro.},
  author={Yaqin Liu and Yesen Li and Yuhong Xu},
  journal={Cell biochemistry and function},
  year={2011},
  volume={29 5},
  pages={429-35}
}
Integrins are critically involved in many tumour-promoting activities. The development of inhibitors against integrins may suppress tumour growth by inhibiting tumour angiogenic signalling. In this study, we investigated the effects of two novel peptides containing the integrin binding arginine-glycine-aspartic acid-motif on inhibiting diverse cell behaviours, including cell adhesion, motility, invasion, tube formation and cell cytoskeleton. Cell adhesion and motility assays demonstrated that… CONTINUE READING
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