Inhibitory effects of nisoldipine and saralasin on angiotensin II-induced antidiuresis in anesthetized dogs.

@article{Kageyama1990InhibitoryEO,
  title={Inhibitory effects of nisoldipine and saralasin on angiotensin II-induced antidiuresis in anesthetized dogs.},
  author={Masanari Kageyama and Yasuo Matsumura and Kazumi Hayashi and Tetsumi Hosokawa and Shinichi Morimoto},
  journal={Japanese journal of pharmacology},
  year={1990},
  volume={52 2},
  pages={245-53}
}
Inhibitory effects of the calcium channel blocker nisoldipine on angiotensin II-induced antidiuresis were investigated in anesthetized dogs, and the findings were compared with those of saralasin. Intrarenal arterial infusion of 10 ng/kg/min angiotensin II resulted in marked decreases in renal blood flow (RBF) and urine formation, with a relatively moderate decrease in glomerular filtration rate. There were marked reductions in the fractional excretion of lithium, which is used as an index of… CONTINUE READING