Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity

@inproceedings{Takaishi2013InhibitoryEO,
  title={Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity},
  author={Masayuki Takaishi and Kunitoshi Uchida and Fumitaka Fujita and Makoto Tominaga},
  booktitle={The Journal of Physiological Sciences},
  year={2013}
}
TRPA1, one of the transient receptor potential channels, has been reported to be involved in nociception and inflammatory pain, suggesting that this molecule could be a promising target for the development of analgesic agents. We screened several monoterpene analogs of camphor, which is known to inhibit human (h) TRPA1, to identify more effective naturally occurring TRPA1 antagonists. Borneol, 2-methylisoborneol, and fenchyl alcohol exhibited higher inhibitory effects on hTRPA1 activity than… CONTINUE READING

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