Inhibitory effects of microRNA-34a on cell migration and invasion of invasive urothelial bladder carcinoma by targeting notch1

@article{ChaoZhang2012InhibitoryEO,
  title={Inhibitory effects of microRNA-34a on cell migration and invasion of invasive urothelial bladder carcinoma by targeting notch1},
  author={超 ChaoZhang张 and Zhiyong Yao 姚志勇 and Mingyang Zhu 朱鸣阳 and 鑫 XinMa马 and Taoping Shi 史涛坪 and Hongzhao Li 李宏召 and Baojun Wang 王保军 and Jinzhi Ouyang 欧阳金芝 and 旭 XuZhang张},
  journal={Journal of Huazhong University of Science and Technology [Medical Sciences]},
  year={2012},
  volume={32},
  pages={375-382}
}
MicroRNAs (miRNAs or miRs) are a class of short, non-coding RNAs that participate in various oncological processes. This study aims to explore the roles of microRNA-34a (miR-34a) in invasive urothelial bladder carcinoma. miR-34a was transfected into bladder cancer cell lines 253J and J82. The miR-34a expression levels in tissues and cells were detected by using qRT-PCR. The Notch1 expression was detected by qRT-PCR and Western blotting. Cell migratory and invasive abilities were measured by… CONTINUE READING

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Urinary BladderIs associated anatomic site ofBladder Neoplasm
Our study concluded that microRNA-34a antagonizes Notch1 and inhibits cell migration and invasion of bladder cancer cells , which indicates the tumor - suppressive function of microRNA-34a in bladder cancer .
Our study concluded that microRNA-34a antagonizes Notch1 and inhibits cell migration and invasion of bladder cancer cells , which indicates the tumor - suppressive function of microRNA-34a in bladder cancer .
Our study concluded that microRNA-34a antagonizes Notch1 and inhibits cell migration and invasion of bladder cancer cells , which indicates the tumor - suppressive function of microRNA-34a in bladder cancer .
Our study concluded that microRNA-34a antagonizes Notch1 and inhibits cell migration and invasion of bladder cancer cells , which indicates the tumor - suppressive function of microRNA-34a in bladder cancer .
Our study concluded that microRNA-34a antagonizes Notch1 and inhibits cell migration and invasion of bladder cancer cells , which indicates the tumor - suppressive function of microRNA-34a in bladder cancer .
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