Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation.

@article{Iizuka2007InhibitoryEO,
  title={Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation.},
  author={Toru Iizuka and Masahiro Nagai and Akemi Taniguchi and Hiroyoshi Moriyama and Keiko Hoshi},
  journal={Biological & pharmaceutical bulletin},
  year={2007},
  volume={30 2},
  pages={382-4}
}
A platelet-aggregatory inhibitor was isolated from the 50% MeOH extract of Phyllanthus niruri L. leaf. Its structure was determined to be methyl brevifolincarboxylate on the basis of the 1H-, 13C-NMR, and high-resolution mass spectral data. We compared the antiplatelet aggregatory effects of the constituent with adenosine, a well-known inhibitor of platelet aggregation. Platelet aggregation was induced by collagen or adenosine 5'-diphosphate as an activating agent; the extent of inhibition was… CONTINUE READING

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