Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells.

@article{Yee2003InhibitoryEO,
  title={Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells.},
  author={Su Bog Yee and Jung Hwa Lee and Hae Young Chung and Kwang Sik Im and Song Ja Bae and Jae Soo Choi and Nam Deuk Kim},
  journal={Archives of pharmacal research},
  year={2003},
  volume={26 2},
  pages={
          151-6
        }
}
We investigated the anti-proliferative effects of luteolin and apigenin, isolated from Ixeris sonchifolia Hance, on HepG2 human hepatocellular carcinoma cells. In MTT assay luteolin showed more efficient anti-proliferative effects on cells than apigenin did. According to propidium iodide staining and flow cytometry studies, we postulated that these effects might be a result of cell cyde arrest. Hence we examined the changes of protein expressions related to cell cycle arrest. Western blotting… CONTINUE READING

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