Inhibitory effects of limonin on six human cytochrome P450 enzymes and P-glycoprotein in vitro.

@article{Han2011InhibitoryEO,
  title={Inhibitory effects of limonin on six human cytochrome P450 enzymes and P-glycoprotein in vitro.},
  author={Yonglong Han and Hong-liang Yu and D. Li and Xiang-le Meng and Z. Zhou and Q. Yu and Xiao-you Zhang and Fu-jing Wang and Cheng Guo},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2011},
  volume={25 8},
  pages={
          1828-33
        }
}
Among the various possible causes for drug interactions, pharmacokinetic factors such as inhibition of drug-metabolizing enzymes and transporters, especially cytochrome P450 (CYP) isoenzymes and P-glycoprotein (P-gp), are regarded as the most frequent and clinically important. Limonin is a widely used dietary supplement and one of the most prevalent citrus limonoids, which are known to have inhibitory effects on CYPs and P-gp. In this study, the in vitro inhibitory effects of limonin on the… Expand
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References

SHOWING 1-10 OF 44 REFERENCES
Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.
  • R. Obach
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 2000
  • 395
  • Highly Influential
  • PDF
Pharmacogenetics of the cytochromes P450.
  • A. Daly
  • Biology, Medicine
  • Current topics in medicinal chemistry
  • 2004
  • 168
Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines.
  • 122
  • PDF
Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions.
  • 299
  • Highly Influential
  • PDF
Grapefruit component interacting with rat and human P450 CYP3A: possible involvement of non-flavonoid components in drug interaction.
  • 70
Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1.
  • 49
Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry.
  • 30
Inhibition and induction of human cytochrome P450 enzymes: current status
  • 465
  • Highly Influential
In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and their Utility for Predicting Drug–Drug Interactions
  • 129
  • Highly Influential
  • PDF
...
1
2
3
4
5
...