Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities: considerations on drug-drug interactions.

@article{Choi2011InhibitoryEO,
  title={Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities: considerations on drug-drug interactions.},
  author={Min-Koo Choi and Qing-Ri Jin and Yeong-Lim Choi and Sung-Hoon Ahn and Myung-Ae Bae and im-sook song},
  journal={Biopharmaceutics & drug disposition},
  year={2011},
  volume={32 3},
  pages={175-84}
}
Ketoconazole and rifampin are the most widely used compounds examined in recent drug-drug interaction (DDI) studies, and they have multiple roles in modulating drug metabolizing enzymes and transporters. To determine the underlying mechanisms of DDI, this study was performed to investigate the inhibitory effects of ketoconazole and rifampin on the functions of OAT1 and OATP1B1, and to evaluate the potential of ketoconazole and rifampin for DDI with substrate drugs for these transporters in a… CONTINUE READING
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