Inhibitory effects of kaempferol-3-O-sophoroside on HMGB1-mediated proinflammatory responses.

@article{Kim2012InhibitoryEO,
  title={Inhibitory effects of kaempferol-3-O-sophoroside on HMGB1-mediated proinflammatory responses.},
  author={Tae Hoon Kim and S M Ku and Jong-Sup Bae},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2012},
  volume={50 3-4},
  pages={1118-23}
}
High mobility group box 1 (HMGB1) protein is secreted by activated cells of the innate immune system and/or released by injured tissues and necrotic cells; HMGB1 up-regulates proinflammatory cytokines in several inflammatory diseases. Kaempferol-3-O-sophoroside (KP) was isolated from the leaves of cultivated mountain ginseng. KP has antitumor, antioxidative, antiallergic and antidiabetic activities, but the effects of KP on HMGB1-mediated proinflammatory responses have not been studied. In this… CONTINUE READING

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Activation of human umbilical vein endothelial cells leads to relocation and release of high - mobility group box chromosomal protein 1

  • M. Olszewska
  • Scand . J . Immunol .
  • 2008
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