Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase

@article{Ozgun2016InhibitoryEO,
  title={Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase},
  author={Dilan Ozmen Ozgun and C. Yamali and H. I. Gul and Parham Taslimi and I. Gulcin and T. Yanık and C. Supuran},
  journal={Journal of Enzyme Inhibition and Medicinal Chemistry},
  year={2016},
  volume={31},
  pages={1498 - 1501}
}
Abstract The effects of isatin Mannich bases incorporating (1-[piperidin-1-yl (P1)/morpholin-4-yl (P2)/N-methylpiperazin-1-yl (P3)]methyl)-1H-indole-2,3-dione) moieties against human (h) carbonic anhydrase (CA, EC 4.2.1.1) isoenzymes hCA I and hCA II, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes were evaluated. P1–P3 demonstrated impressive inhibition profiles against AChE and BChE and also inhibited both CAs at nanomolar level. These inhibitory effects were more… Expand
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