Inhibitory effects of hyaluronan on [14C]arachidonic acid release from labeled human synovial fibroblasts.

  title={Inhibitory effects of hyaluronan on [14C]arachidonic acid release from labeled human synovial fibroblasts.},
  author={Kenji Tobetto and Takahiro Yasui and Tetsuya Ando and M. Hayaishi and Noboru Motohashi and M. Shinogi and Ikuko Mori},
  journal={Japanese journal of pharmacology},
  volume={60 2},
The effects of hyaluronan (HA) on the release of arachidonic acid (AA) from phospholipids induced by bradykinin in synovial fibroblasts of osteoarthritic patients were examined. HA inhibited [14C]AA release from prelabeled synovial cells stimulated with and without bradykinin 1 hr after incubation with HA and thereafter. The inhibitory effects of HA on [14C]AA release were dependent on the concentration and molecular weight of HA. However, inhibition of [14C]AA release by HA was not merely due… CONTINUE READING

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