Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells.

@article{Wu2011InhibitoryEO,
  title={Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells.},
  author={Fang Wu and Wei Zhang and Lin Li and Fenping Zheng and Xueting Shao and Jia-qiang Zhou and Hong Li},
  journal={European journal of pharmacology},
  year={2011},
  volume={654 1},
  pages={117-21}
}
Honokiol has been shown to possess a lot of pharmacologic benefits, including antioxidative, antiangiogenic and antineoplastic effects. In the present study, we investigated the anti-inflammatory effects of honokiol and the signaling mechanisms involved in lipopolysaccharide (LPS)-induced conditions in human renal mesangial cells (HRMCs). Honokiol did not significantly change HRMC viability when used at a concentration of <20 μmol/l but markedly altered cell viability at concentrations of >40… CONTINUE READING

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