Inhibitory effects of herbal extracts on breast cancer resistance protein (BCRP) and structure-inhibitory potency relationship of isoflavonoids.

@article{Tamaki2010InhibitoryEO,
  title={Inhibitory effects of herbal extracts on breast cancer resistance protein (BCRP) and structure-inhibitory potency relationship of isoflavonoids.},
  author={Hirofumi Tamaki and Hiroki Satoh and Satoko Hori and Hisakazu Ohtani and Yasufumi Sawada},
  journal={Drug metabolism and pharmacokinetics},
  year={2010},
  volume={25 2},
  pages={
          170-9
        }
}
The inhibition of intestinal breast cancer resistance protein (BCRP), which restricts the absorption of xenobiotics, may increase the systemic availability of its substrates. The aim of this study was to evaluate the inhibitory effects of herbal extracts and their constituents on BCRP-mediated transport. The inhibitory effects of 9 herbal extracts and 23 isoflavonoids, including soybean-derived isoflavones, on BCRP-mediated methotrexate (MTX) transport were evaluated using BCRP-expressing… Expand
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