Inhibitory effects of hepatocyte growth factor and interleukin-6 on transforming growth factor-beta1 mediated vocal fold fibroblast-myofibroblast differentiation.

@article{Vyas2010InhibitoryEO,
  title={Inhibitory effects of hepatocyte growth factor and interleukin-6 on transforming growth factor-beta1 mediated vocal fold fibroblast-myofibroblast differentiation.},
  author={Bimal Vyas and Keiko Ishikawa and S. Gustave Dit Duflo and Xia Chen and Susan L Thibeault},
  journal={The Annals of otology, rhinology, and laryngology},
  year={2010},
  volume={119 5},
  pages={350-7}
}
OBJECTIVES The role of myofibroblasts in vocal fold scarring has not been extensively studied, partly because of the lack of a robust in vitro model. The objective of this investigation was to develop and characterize a myofibroblast in vitro model that could be utilized to investigate the molecular mechanism of myofibroblast differentiation and function in injured vocal fold tissue. METHODS Differentiation of human primary vocal fold fibroblasts (hVFFs) to myofibroblasts was stimulated with… CONTINUE READING
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