Inhibitory effects of gold sodium thiomalate on DNA polymerase alpha.

Abstract

The usefulness of gold compounds in the therapy of rheumatoid arthritis is well established, however, the pharmacological mechanisms of the compounds are still unclear. In this report, effects of gold compounds on DNA synthesis were examined. Gold sodium thiomalate inhibited DNA synthesis in the HeLa "nuclei system" as well as in the enzyme reaction using… (More)

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@article{Takeuchi1989InhibitoryEO, title={Inhibitory effects of gold sodium thiomalate on DNA polymerase alpha.}, author={Fujio Takeuchi and Fumio Hanaoka and Kunio Matsuta and Toshihiro Miyamoto}, journal={Clinical and experimental rheumatology}, year={1989}, volume={7 6}, pages={595-601} }