Inhibitory effects of cerulenin on protein palmitoylation and insulin internalization in rat adipocytes.

@article{Jochen1995InhibitoryEO,
  title={Inhibitory effects of cerulenin on protein palmitoylation and insulin internalization in rat adipocytes.},
  author={A L Jochen and John Hays and Gail Mick},
  journal={Biochimica et biophysica acta},
  year={1995},
  volume={1259 1},
  pages={65-72}
}
Protein acylation by long-chain fatty acids has been suggested as a necessary step in membrane trafficking. Because several insulin effects are dependent upon membrane trafficking, the cellular effects of the protein acylation inhibitor cerulenin were examined. Cerulenin blocked palmitoylation of selected rat adipocyte proteins including CD36, the dominant marker for palmitoylation in adipocytes. To measure cerulenin's effects on insulin internalization, rat adipocytes were incubated with 125I… CONTINUE READING

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