Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture.

@article{Kozuki2000InhibitoryEO,
  title={Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture.},
  author={Yasuhiro Kozuki and Yoshihiko Miura and Kazumi Yagasaki},
  journal={Cancer letters},
  year={2000},
  volume={151 1},
  pages={111-5}
}
The effects of carotenoids--alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, zeaxanthin, lutein, canthaxanthin, astaxanthin--on the invasion of rat ascites hepatoma AH109A cells were investigated by co-culturing the hepatoma cells with rat mesentery-derived mesothelial cells (M-cells). All the carotenoids examined inhibited AH109A invasion in a dose-dependent manner up to 5 microM. Cancer cells previously cultured with hypoxanthine (HX) and xanthine oxidase (XO) showed a highly… CONTINUE READING