Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice

@article{Iigo1999InhibitoryEO,
  title={Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice},
  author={Masaaki Iigo and Tetsuya Kuhara and Yoshihiko Ushida and Kazunori Sekine and Malcolm A. S. Moore and Hiroyuki Tsuda},
  journal={Clinical & Experimental Metastasis},
  year={1999},
  volume={17},
  pages={43-49}
}
In order to determine the effects of the multifunctional iron-binding glycoprotein, lactoferrin (LF), and related compounds on tumor growth and metastasis, bovine LF (bLF), and bLF hydrolysate and lactoferricin (bLFcin), active products generated by acid-pepsin hydrolysis were administered orally to BALB/c mice bearing subcutaneous (s.c.) implants of the highly metastatic colon carcinoma 26 (Co 26Lu). bLF and the bLF hydrolysate demonstrated significant inhibition of lung metastatic colony… CONTINUE READING
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