Inhibitory effects of azelastine hydrochloride on Ca2+ influx, actin polymerization and release of eosinophil cationic protein of an eosinophilic leukaemia cell line EoL-1.

@article{Morita1993InhibitoryEO,
  title={Inhibitory effects of azelastine hydrochloride on Ca2+ influx, actin polymerization and release of eosinophil cationic protein of an eosinophilic leukaemia cell line EoL-1.},
  author={Manabu Morita and Yukio Ohshima and Hideyasu Akutagawa and Yasuaki Uenoyama and Masaji Nambu and Mitsufumi Mayumi and Haruki Mikawa},
  journal={Current medical research and opinion},
  year={1993},
  volume={13 3},
  pages={
          163-74
        }
}
The inhibitory effects of azelastine hydrochloride on PAF-induced and fMLP-induced Ca2+ influx, actin polymerization and calcium ionophore A23187-induced and aggregated IgG-induced release of eosinophil cationic protein (ECP) of an eosinophilic leukaemia cell line, EoL-1, were examined. EoL-1 cells cultured with 0.2 mM dibutyryladenosine-cyclic monophosphate for 48 hours showed an increase in intracellular free Ca2+ concentration ([Ca2+]i) and actin polymerization when stimulated by PAF and… CONTINUE READING
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