Inhibitory effects of autoantibodies on the muscarinic receptors in Sjögren's syndrome

  title={Inhibitory effects of autoantibodies on the muscarinic receptors in Sj{\"o}gren's syndrome},
  author={Jingchao Li and Young-min Ha and Na-Youn K{\"u} and Se-Young Choi and Sung Joong Lee and Seog Bae Oh and Joong-soo Kim and Jong-Ho Lee and Eun Bong Lee and Yeong Wook Song and Kyungpyo Park},
  journal={Laboratory Investigation},
Sjögren's syndrome (SS) is a systemic autoimmune disease that involves reduced salivary secretions. Recently, circulating autoantibodies from SS patients against the type 3 muscarinic cholinergic receptor (M3R) has been reported in the sera of SS patients. However, the role of these autoantibodies in the development of SS has not been elucidated. In this study, purified IgG was obtained from the sera of 11 SS patients, and its inhibitory effect on the M3R of the salivary glands was evaluated… CONTINUE READING


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