Inhibitory effects of anti-miRNA oligonucleotides (AMOs) on A549 cell growth.

  title={Inhibitory effects of anti-miRNA oligonucleotides (AMOs) on A549 cell growth.},
  author={Jia Fei and Feiei Lan and Ming Le Guo and Yumin Li and Yu Liu},
  journal={Journal of drug targeting},
  volume={16 9},
MicroRNAs (miRNAs) are a new class of non-protein-coding, endogenous small RNA molecules of 18-24 nt in size. miRNAs can specifically down-regulate gene expression involved in proliferation, apoptosis, and differentiation in cancer cells. Our purpose was to identify several functional miRNAs as potential drug targets by using specific antisense-microRNA oligonucleotides (AMOs), and to study the inhibitory effects of these AMOs on A549 cell growth. miR-16, miR-21, miR-214, and miR-181a were… CONTINUE READING
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