Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.

@article{Yamashita2006InhibitoryEO,
  title={Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.},
  author={Fumiaki Yamashita and Hisakazu Ohtani and Noriko Koyabu and Fumihiko Ushigome and Hiroki Satoh and Hideyasu Murakami and Takeshi Uchiumi and Takanori Nakamura and Michihiko Kuwano and Masayuki Tsujimoto and Yasufumi Sawada},
  journal={The Journal of pharmacy and pharmacology},
  year={2006},
  volume={58 11},
  pages={1499-505}
}
Human organic anion transporter 4 (OAT4) is the only member of the OAT family that is expressed in the placenta and also expressed in kidney. Although OAT4 has been shown to transport certain organic anions as well as other members of the OAT family, fewer numbers of substrates have been identified for OAT4 compared with OAT1 and OAT3, suggesting that the substrate specificity of OAT4 is greater than other OAT members. However, the substrate specificity of OAT4 remains to be investigated in… CONTINUE READING