Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response.

@article{Boulet1997InhibitoryEO,
  title={Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response.},
  author={Louis-Philippe Boulet and Kenneth R Chapman and Johanne C{\^o}t{\'e} and Shashank Singh Kalra and Rajesh Bhagat and Veronica A Swystun and Michel Laviolette and Linda Cleland and Francine Deschesnes and John Q. Su and A. Damien Devault and Robert B. Fick and Donald W. Cockcroft},
  journal={American journal of respiratory and critical care medicine},
  year={1997},
  volume={155 6},
  pages={1835-40}
}
Inhaled allergens, acting through IgE-dependent mechanisms, are important triggers of asthma symptoms and inducers of airway hyperresponsiveness and airway inflammation. The effect of anti-IgE recombinant humanized monoclonal antibody-E25 (rhuMAb-E25) on the provocation concentration of allergen causing a 15% fall in FEV1 (allergen PC15) during the allergen-induced early asthmatic response (EAR) was assessed in a multicenter, randomized, double-blind, parallel group study. Ten of 11 allergic… CONTINUE READING

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