Inhibitory effects of advanced glycation end-products and Porphyromonas gingivalis lipopolysaccharide on the expression of osteoblastic markers of rat bone marrow cells in culture.

@article{Sakamoto2016InhibitoryEO,
  title={Inhibitory effects of advanced glycation end-products and Porphyromonas gingivalis lipopolysaccharide on the expression of osteoblastic markers of rat bone marrow cells in culture.},
  author={Eijiro Sakamoto and Chie Mihara and Takahisa Ikuta and Yuji Inagaki and Jun-Ichi Kido and Toshihiko Nagata},
  journal={Journal of periodontal research},
  year={2016},
  volume={51 3},
  pages={313-20}
}
BACKGROUND AND OBJECTIVES Diabetes is a major risk factor for periodontitis and there is a close relationship between the degree of hyperglycemia and the severity of periodontitis. Advanced glycation end-products (AGEs) accumulate in various tissues under diabetic conditions. AGEs in the periodontal tissues probably play a role in upregulating periodontal inflammation; however, the association of AGEs with the severity of periodontitis has not been fully clarified. Lipopolysaccharide from… CONTINUE READING
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